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Filtered Search Results
![Medchemexpress LLC 6-amino-2-[(2S)-pentan-2-yl]oxy-9-(5-piperidin-1-ylpentyl)-7H-purin-8-one | 1207629-49-9 | 99.8% | 390.52 g/mol | C20H34N6O2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000226248.png-250.jpg)
Medchemexpress LLC 6-amino-2-[(2S)-pentan-2-yl]oxy-9-(5-piperidin-1-ylpentyl)-7H-purin-8-one | 1207629-49-9 | 99.8% | 390.52 g/mol | C20H34N6O2 | 10 MG
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GSK2245035 is a selective Toll-like receptor 7 (TLR7) agonist developed for intranasal research use. It preferentially stimulates type-I interferon responses and has been investigated in clinical studies of allergic rhinitis and allergen-induced asthmatic responses. Supplied as a solid research reagent for laboratory use.
- Selective TLR7 agonist with preferential type-I interferon stimulation.
- Investigated in clinical pharmacology for allergen and asthma models.
- High purity: 99.79% reported by supplier.
- Physical form: solid, off-white to light yellow.
- Packaged for research: 10 MG single vial.
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![eMolecules AstaTech / 23-DIHYDRO[14]DIOXINO[23-B]PYRIDINE-7-SULFONYL CHLORIDE / 0.1g / 600864181 / E72242 / 95.000 / 1823887-47-3 / MFCD26516572 / 235.640 / C7H6ClNO4S](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475821.JPG-250.jpg)
eMolecules AstaTech / 23-DIHYDRO[14]DIOXINO[23-B]PYRIDINE-7-SULFONYL CHLORIDE / 0.1g / 600864181 / E72242 / 95.000 / 1823887-47-3 / MFCD26516572 / 235.640 / C7H6ClNO4S
AstaTech / 23-DIHYDRO[14]DIOXINO[23-B]PYRIDINE-7-SULFONYL CHLORIDE / 0.1g / 600864181 / E72242 / 95.000 / 1823887-47-3 / MFCD26516572 / 235.640 / C7H6ClNO4S
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![eMolecules Medchem Express / GSK778 / 5mg / 588504719 / HY-136570 / / 2451862-42-1 / [null] / 511.626 / C30H33N5O3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475960.JPG-250.jpg)
eMolecules Medchem Express / GSK778 / 5mg / 588504719 / HY-136570 / / 2451862-42-1 / [null] / 511.626 / C30H33N5O3
Medchem Express / GSK778 / 5mg / 588504719 / HY-136570 / / 2451862-42-1 / [null] / 511.626 / C30H33N5O3
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eMolecules Medchem Express / Bephenium (hydroxynaphthoate) / 100mg / 446261559 / HY-12639A / / 3818-50-6 / MFCD00078960 / 443.543 / C28H29NO4
Medchem Express / Bephenium (hydroxynaphthoate) / 100mg / 446261559 / HY-12639A / / 3818-50-6 / MFCD00078960 / 443.543 / C28H29NO4
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eMolecules Ambeed / 2-(Phenylthio)nicotinic acid / 250mg / 600849709 / A904354 / / 35620-72-5 / MFCD00052110 / 231.270 / C12H9NO2S
Ambeed / 2-(Phenylthio)nicotinic acid / 250mg / 600849709 / A904354 / / 35620-72-5 / MFCD00052110 / 231.270 / C12H9NO2S
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![eMolecules Medchem Express / Banoxantrone-d12 (dihydrochloride) / 1mg / 446263123 / HY-13562AS / / 1562066-98-1 / [null] / 529.480 / C22H30Cl2N4O6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502477185.JPG-250.jpg)
eMolecules Medchem Express / Banoxantrone-d12 (dihydrochloride) / 1mg / 446263123 / HY-13562AS / / 1562066-98-1 / [null] / 529.480 / C22H30Cl2N4O6
Medchem Express / Banoxantrone-d12 (dihydrochloride) / 1mg / 446263123 / HY-13562AS / / 1562066-98-1 / [null] / 529.480 / C22H30Cl2N4O6
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Medchemexpress LLC Pseudoprotodioscin | 102115-79-7 | 1031.18 | 20 MG
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Pseudoprotodioscin is a furostanoside that inhibits SREBP1/2 and microRNA 33a/b levels, leading to a reduction in gene expression related to the synthesis of cholesterol and triglycerides. In Hep G2 cells, it increases ABCA1 protein and mRNA levels and promotes the efflux of ApoA-1-mediated cholesterol. It also inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels, which reciprocally increases ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin reduces HMGCR, FAS, and ACC mRNA levels and promotes low-density lipoprotein receptor by decreasing PCSK9 levels.
- Inhibits SREBP1/2 and microRNA 33a/b levels.
- Reduces gene expression concerning cholesterol and triglyceride synthesis.
- Increases ABCA1 protein and mRNA levels.
- Promotes ApoA-1-mediated cholesterol efflux.
- Reduces HMGCR, FAS, and ACC mRNA levels.
- Promotes low-density lipoprotein receptor by decreasing PCSK9 levels.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC αvβ1 integrin-IN-1 | 1689540-62-2 | 99.5% | 558.65 g/mol | C26H34N6O6S | 10 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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αvβ1 integrin-IN-1 is a small-molecule, selective inhibitor of αvβ1 integrin with potent activity (IC50 0.63 nM) and reported antifibrotic effects. It is available as the free base and as a TFA salt, supplied as solids and as a 10 mM solution in DMSO. The compound has molecular formula C26H34N6O6S, molecular weight 558.65 g/mol, and CAS 1689540-62-2, provided at high purity for research use.
- Potent αvβ1 inhibition with IC50 0.63 nM.
- Demonstrated antifibrotic activity in relevant assays.
- Available as solid quantities and as a 10 MG DMSO solution (10 mM, 1 mL).
- High purity suitable for biochemical and cell-based studies.
- Supplied in both free base and TFA salt forms.
- Molecular formula C26H34N6O6S; molecular weight 558.65 g/mol.
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eMolecules Ambeed / 2-(Pyridin-3-yl)acetic acid hydrochloride / 5g / 552614658 / A172627 / / 6419-36-9 / MFCD00012819 / 173.600 / C7H8ClNO2
Ambeed / 2-(Pyridin-3-yl)acetic acid hydrochloride / 5g / 552614658 / A172627 / / 6419-36-9 / MFCD00012819 / 173.600 / C7H8ClNO2
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eMolecules Ambeed / 2-Hydroxy-3-isopropylbenzoic acid / 250mg / 624121347 / A526627 / / 7053-88-5 / MFCD00075272 / 180.203 / C10H12O3
Ambeed / 2-Hydroxy-3-isopropylbenzoic acid / 250mg / 624121347 / A526627 / / 7053-88-5 / MFCD00075272 / 180.203 / C10H12O3
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC MS4078 anaplastic lymphoma kinase (ALK) PROTAC degrader | 2229036-62-6 | 99.7% | 914.47 | 100 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC degrader based on a Cereblon ligand, demonstrating a Kd of 19 nM for binding affinity to ALK. This product is intended for research use only and is not suitable for patient use.
- Anaplastic lymphoma kinase (ALK) PROTAC degrader
- Based on Cereblon ligand
- 19 nM Kd for binding affinity to ALK
- Inhibits proliferation of SU-DHL-1 cells with an IC50 of 33 nM
- Reduces NPM-ALK protein levels in SU-DHL-1 cells
- Reduces EML4-ALK protein levels in NCI-H2228 cells
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules Ambeed / 5-(tert-Butyl)-2-methoxybenzoic acid / 1g / 633418811 / A516025 / / 73469-54-2 / MFCD02093964 / 208.257 / C12H16O3
Ambeed / 5-(tert-Butyl)-2-methoxybenzoic acid / 1g / 633418811 / A516025 / / 73469-54-2 / MFCD02093964 / 208.257 / C12H16O3
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules Ambeed / Picolinohydrazide / 1g / 525098731 / A181361 / / 1452-63-7 / MFCD00059782 / 137.142 / C6H7N3O
Ambeed / Picolinohydrazide / 1g / 525098731 / A181361 / / 1452-63-7 / MFCD00059782 / 137.142 / C6H7N3O
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Enzo Life Sciences Pseudohypericin (1mg). CAS: 55954-61-5
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Inhibitor of protein kinase C (PKC) (IC50=15µg/ml). Antiviral and antiretroviral activity. Potent inhibitor of dopamine-β-hydroxylase (IC50=3µg/ml). Purity: ≥98% (HPLC, TLC). Appearance: Black to black-red powder. Solubility: Soluble in methanol, 100% ethanol, DMSO, acetone and other organic solvents. Long Term Storage: +4°C.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Fenofibrate | 49562-28-9 | 99.92% | 360.83 | 100 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Fenofibrate (Standard) is the analytical standard of Fenofibrate, intended for research and analytical applications. It is a selective PPARα agonist with an EC50 of 30 μM and also inhibits human cytochrome P450 isoforms. This analytical standard is commonly used in qualitative, quantitative, and methodological research experiments.
- Used in HPLC, GC, and MS experiments
- Reference standard for assay
- Selective PPARα agonist
- Inhibits human cytochrome P450 isoforms
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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